1920s, Scientists have known the existence of Human Growth Hormone.
1958, Scientists began to apply HGH on children that suffer from dwarfism to help them grow normally. The effects were very obvious. The theory behind the use of HGH in those days was that the pituitary gland, which secrets HGH, was either defective or not functioning at all in those children with dwarfism. The main source of HGH for treatment at that time was extracted from the pituitary glands of dead people in Africa. It often took thousands of brains of the dead to produce just a few drops of HGH! Scientists were, therefore, forced to research alternatives such as synthetic HGH.
1985, Dr. Daniel Rudman, a Wisconsin internal medicine scholar, first published in the Journal of American Geriatrics Society a brand new theory about aging based on his many years of extensive clinical experiments and research. He indicated clearly in the article that human aging is a result of HGH deficiency, and is not the commonly accepted view of “inevitable natural phenomenon.” He further concluded that by stimulating the pituitary gland with HGH, the gland could be made to recover its function to secrete HGH again. This discovery not only stops the aging process but also turns back the biological clock to its adolescent stage. 1985, Genentech succeeded in producing large quantities of HGH through microbiological
1985, Genentech succeeded in producing large quantities of HGH through microbiological replication by inserting human DNA into microorganisms. Normal HGH has 191 amino acids, whereas Genentech’s HGH had only 190.
1986, Eli Lilly was able to produce HGH with 191 amino acids by using bio-engineering of the genes.
1990, Dr. Daniel Rudman published another article in the New England Journal of Medicine that shocked the entire medical fields. This article became a milestone in anti-aging treatment with the clinical trials of HGH. He selected 12 males, aged from 61 to 81 for treatment. After 6 months’ use of HGH, their fat was reduced by 14.4%; skin thickness increased 7.11%; bone density increased 1.6%; liver improved 19% and spleen improved 17%. Dr. Rudman concluded that these 12 old men had become younger by 20 years both physically and psychologically.
1992, Encouraged by Dr. Rudman’s HGH theory, the National Institute on Aging began to carry out nine clinical experiments that took 5 years to complete. The results, unprecedented and far-reaching in influence, proved once again that Dr. Rudman’s theory was correct.
1996, Dr. Rudman had over 800 HGH patients, including movie stars, corporate executives, other renowned doctors, specialists and scholars. In his medical reports, he indicated that among thousands of patients, there was not even one single case of failure.
Within the past ten years, there were more than 30,000 case reports, the results were very encouraging.
1996, FDA finally approved the usage of HGH in the treatment of both children and adults for suffering from growth hormone deficiency. It is now recognized in the medical fields that HGH is the major hormone among all hormones. It guides and promotes the release and secretion of other hormones.
Prior to the advent of recombinant DNA technology, the only source of growth hormone was from human cadavers. More than 27,000 children worldwide were treated with growth hormone of this source (pit-hGH). Due to short supply, children were treated with low doses and interrupted regimens. As a result, their response and ultimate height was mitigated. Distribution of pit-hGH was stopped in the United States and most of Europe in 1985, with the emergence of Creutzfeldt-Jakob Disease. This is a rare and fatal spongiform encephalopathy, caused by a small pathogen called a prion. This is the same pathogen that causes “Mad Cow Disease” recently seen in Europe from infected cattle. It is impossible to catch Creutzfeldt-Jakob Disease or any other infection from recombinant human growth hormone because it is not derived from a human or animal source, but from a purified tissue culture. For purposes of this discussion, the term growth hormone, GH or hGH will mean growth hormone made by recombinant DNA technology.
The bio-potency of commercially available growth hormone is typically represented by either milligrams or units. To put it simply, 1 milligram of growth hormone is equivalent to 3 units. The international units were developed by the World Health Organization in order to standardize growth hormone preparations because of the various production techniques used early on in the manufacturing process. By now, the manufacturing process has been streamlined and largely perfected so the bio-equivalency of the various brands of growth hormone (at least those manufactured and approved by the FDA for sale in the United States) are identical. Therefore, a typical 15-unit vial of growth hormone contains 5 mg, and a 4-unit vial contains 1.33 mg.
